Sinclair Method Studies
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.

Understanding the science of addiction is crucial for anyone on the path to recovery or supporting a loved one through it. At the core of addiction lies a powerful biochemical mechanism driven by the brain’s natural reward system—most notably, endorphins. These feel-good chemicals play a pivotal role in reinforcing behaviours, and when substances like alcohol exploit this system, the result can be a cycle that’s difficult to break.
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